Professor of Neurosurgery, Tehran University of Medical Sciences and Health Services, Sina Hospital, Tehran, Iran
Abstract
Introduction & objective: The third common primary intracranial tumors are pituitary adenomas. Atypical pituitary tumors are characterized by MIB-1>3% & significant P53 nuclear staining. The aim of this study is to evaluate the relationship of the mutant P-53 & MIB-1 level with the outcome of these tumors. Materials & Methods: This Cohort study is conducted in both retrospective & prospective phases from April 2013 to October 2015, 83 patients were enrolled, and inclusion criteria were presence of radiological, clinical or endocrinologic evidence of functional or non-functional pituitary adenomas. Besides, all the patients underwent surgery, whether trans-sphenoidal or trans-cranial, for evacuation of adenomas. Follow-up radiologic and clinical evaluation were done 6 weeks, 6months, and one year after the surgery in all the cases. Results: The non-functional tumors were significantly more aggressive (82.2% versus 55.3% in functional adenomas) (P=0.008). No significant relationship was found between outcome MIB-1 & P53 levels (P=0.49, P=0.834 respectively). On the other hand, invasiveness was significantly related to outcome (39 patients (84.7%) with unaccepted outcome and 19 (51.3%) cases with accepted outcome were invasive, P=0.001). Conclusions: Among invasiveness & MIB-1 & P-53 level, the role reliable prognostic factors for anticipating the outcome seems to be invasiveness and the other factors can be just assumed as confounder factors.
Shirani BidAbadi, M., Amirjamshidi, A., Karimi Yarandi, K., Moradi Tabriz, H., Hossaini, S. & Ghazi Mirsaeed, S. (2016). Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas. Iranian Journal of Surgery, 24(Summer), 20-30.
MLA
Shirani BidAbadi, M., Amirjamshidi, A., Karimi Yarandi, K., Moradi Tabriz, H., Hossaini, S., & Ghazi Mirsaeed, S. "Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas", Iranian Journal of Surgery, 24, Summer, 2016, 20-30.
HARVARD
Shirani BidAbadi M., Amirjamshidi A., Karimi Yarandi K., Moradi Tabriz H., Hossaini S., Ghazi Mirsaeed S. (2016). 'Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas', Iranian Journal of Surgery, 24(Summer), pp. 20-30.
CHICAGO
M. Shirani BidAbadi, A. Amirjamshidi, K. Karimi Yarandi, H. Moradi Tabriz, S. Hossaini & S. Ghazi Mirsaeed, "Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas," Iranian Journal of Surgery, 24 Summer (2016): 20-30,
VANCOUVER
Shirani BidAbadi M., Amirjamshidi A., Karimi Yarandi K., Moradi Tabriz H., Hossaini S., Ghazi Mirsaeed S. Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas. Iranian Journal of Surgery. 2016;24(Summer):20-30.
