Journal Title: تابستان 92
Article title: Evaluation of the Hemostatic Effect of Ferric Sulphate in Controlling External Bleeding in Mouse at Kashan University of Medical Sciences, 2012

Article PDF File:
Page From: 37 To: 44      
Article abstract:
Introduction & Objective: The control of external bleeding, despite progresses in surgical science, is still one of the challenges surgeons face in saving patients’ lives. There is a research contest among the researchers in this field to introduce a more effective method. This study attempts to determine the hemostatic effect of ferric sulfate in controlling external bleeding. Materials & Methods: In this clinical trial 60 male Wistar rats were used. A 2-centimeter incision was made on each mouse’s skin and the hemostasis time was measured, using ferric sulfate with different concentrations (5.0%, 10.0%, 15.0%, 25%, and 50%) and the control method (i.e. control of bleeding by suturing). The skin tissue was assessed for pathological changes. Finally, the obtained data were entered into SPSS software and were analyzed by using Kruskal-Wallis test, Mann - Whitney, Kolmogorov – Smirnov test and also Wilcoxon signed ranks test. Results: The hemostasis time of ferric sulfate concentration groups was significantly less than that of the control group (P-value < 0.001) and the pathologic examination showed the most frequency of low grade inflammation, based on the defined pathological grading. Conclusions: Ferric sulfate may be an effective hemostatic agent in controlling an external bleeding in mouse.
Article KeyWords:
External Bleeding, Hemostatic, Ferric Sulphate
Article Authors:

	دکتر سعید نوری	First Author
	دکتر مهدیه امیر بیگی	Other Author	mahdieh391@yahoo.com
	دکتر مهرداد حسین‌پور	Other Author
	دکتر اسمعیل عبدالرحیم کاشی	Other Author
	دکتر محمد رضا شریف	Other Author
	دکتر محمد کاظم امیربیگی	Other Author