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صاحب امتیاز:جامعه جراحان ایران
مدیر مسئول:دکتر ایرج فاضل
سردبیر: دکتر مصطفی جابـرانصاری
مدیر اجرایی:دکتر شیوا گلشنی

آدرس:تهران - دفتر مرکزی جامعه جراحان ایران-خیابان میرداماد- شماره 175-
کد پستی:1919913961
تلفن:30-26401420
دورنگار:22271119
پست الکترونیک:info@ijs.ir

صفحه نخست :: بخش مدیریت نشریهصفحه قبل

Journal Title: بهار 97
Article title: Evaluation of the Effectiveness of Sodium Hyaluronate, Sesame Oil, Honey and Silver Nanoparticles in Preventing Postoperative Surgical Adhesion Formation

Article PDF File:
Page From: 47 To: 54      

Article abstract:
Introduction & Objective: Postoperative surgical adhesion is a common consequence of intraperitoneal surgery which may lead to several complications such as adhesive small bowel obstructions, chronic abdominopelvic pain, and female infertility making a significant adverse impact on health care costs. Many efforts have been made aiming to decrease the rate of postoperative surgical adhesion formation. We conducted the present experimental study aiming to evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation. Materials & Methods: Our study was conducted in Hamadan University of Medical Sciences, Hamadan, Iran during 2015 and 2016. Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. They were housed in 21°C temperature and 60% ± 5 humidity. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale. Statistical analyses were performed by using SPSS software (IBM SPSS Statistics for Windows, Version 20.0, IBM Corp., Armonk, NY, USA). Quantitative and qualitative data were analyzed using the Kruskal-Wallis and Mann-Whitney U test, respectively. Statistical significance was defined by (P < 0.05). Results: The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale. Conclusions: Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.

Article KeyWords:
Hyaluronate, Sesame Oil, Surgical Adhesion, Silver Nanoparticles

Article Authors:
دکتر حمید رضا خورشیدیFirst Author
دکتر غلام رسول کمال پورOther Author
دکتر محمد حسینی پناهOther Authormohammadhosseinipanah@yahoo.com




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