نام كاربري
كلمه ورود
درخواست عضویت
کلمه ورود را فراموش کرده ام

صاحب امتیاز:جامعه جراحان ایران
مدیر مسئول:دکتر ایرج فاضل
سردبیر: دکتر مصطفی جابـرانصاری
مدیر اجرایی:دکتر شیوا گلشنی

آدرس:تهران - دفتر مرکزی جامعه جراحان ایران-خیابان میرداماد- شماره 175-
کد پستی:1919913961
تلفن:30-26401420
دورنگار:22271119
پست الکترونیک:info@ijs.ir

صفحه نخست :: بخش مدیریت نشریهصفحه قبل

Journal Title: بهار 97
Article title: The Association between Serum Vitamin D Level with Breast Cancer and ER/PR, Her-2 in North of Iran

Article PDF File:
Page From: 38 To: 46      

Article abstract:
Introduction & Objective: Breast cancer is one of the most common cancers in women throughout the world including Iran. There are currently more than 40000 women in Iran suffering from the disease. Studies have shown that the active form of vitamin D, increases cell differentiation and inhibits proliferation, can play a role in changing the risk of breast cancer. Materials & Methods: Present study is analytical and case-control study. In this study150 women with breast cancer and150 women without breast cancer as control were investigated. Including criteria was diagnosis of breast cancer in all cases and absence breast cancer in all control group. Serum vitamin D level, age and marital data included in check list. The obtained data were subjected to chi square, logistic regression and two samples t-test by SPSS software version 23. In all analyses P ˂ 0.05 were as significant difference. Results: Mean level of serum vitamin D in case and control groups were 16.73 ± 11.95 and‌ 27.04 ± 18.49 ng/ml, respectively (‌P < 0.001). Based on multivariable analysis of logistic regression, the risk of developing breast cancer increased with a decrease in serum vitamin D levels. At the level of vitamin deficiency (10 > ng/ml), the odds ratio of illness were 1.93 times higher than the inadequate level. (%95 CI: 0.281; 0.954, P = 0.035), and the odds ratio of getting the disease were 6.9 times higher than the adequate level of vitamin D (%95 CI: 0.075; 0.361, ‌P < 0.001). Also, the serum vitamin D level with estrogen receptors and progesterone receptors was significantly correlated‌ (P‌ < 0.001), but there was no significant correlation with HER-2 receptor ‌(P = 0.195). Conclusions: Based on this study, patients with breast cancer had significantly lower levels of serum vitamin D in comparison with healthy women. Therefore, decreases in serum vitamin D levels are associated with an increased risk of breast cancer.

Article KeyWords:
Serum Vitamin D, Breast Cancer Disease, Receptor Estrogen, Progestron

Article Authors:
دکتر فاطمه نعمتیFirst Author
دکتر سپیده سیادتیOther Author
دکتر معصومه کریمیOther Author
دکتر ثریا خفریOther Author
سکینه کمالی آهنگرOther Author
دکتر شهره عالیان سماک خواهOther Author
دکتر نوین نیک بخشOther Authornovinsu@hotmail.com




بالای صفحه
صفحه اصلی  |  تماس با ما  |  آرشیو مجله  |  نقشه سایت  |  عضویت  |  ارسال مقاله  |  پیگیری مقاله

استفاده از مطالب این سایت با ذکر نام سایت مجاز می باشد   -   Copyright © 2007, 2009 - Last Update 5-11-2009
Powered By www.itpco.net    www.itpco.ir
( ITPCO ) شرکت توسعه انفورماتیک ایران
تولید کننده سیستم های تخصصی مدیریت نشریات و همایش ها و مورد تائید کمیسیون نظارت بر نشریات پزشکی وزارت بهداشت درمان و آموزش پزشکی کشور